WebSide Effects. Important things to remember about the side effects of alectinib: Most people will not experience all of the alectinib side effects listed. Side effects are often … WebUse: Labeled Indications. Non-small cell lung cancer, metastatic: Treatment of anaplastic lymphoma kinase (ALK)-positive, metastatic non-small cell lung cancer (NSCLC) as detected by an approved test. Alectinib description. Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase.
Alectinib - Side Effects, Uses, Dosage, Overdose, Pregnancy
WebBased on findings from animal studies and its mechanism of action, alectinib can cause fetal harm when administered to pregnant women (see Pregnancy) Renal impairment occurred; incidence of Grade ≥3 renal impairment was 1.7%, of which 0.5% were fatal events (see Dosage Modifications) Hemolytic anemia reported, including cases associated with ... WebRarely, side effects reported in people taking this drug have been deadly. These include bleeding problems, kidney problems, trouble breathing, pneumonia, a hole in the bowel, blood clots in the lungs, a heart infection called endocarditis, or the heart stopped working. Talk with your doctor if you have questions. cumberland county penndot office
alectinib - Macmillan Online Community
WebYou may report side effects to Health Canada at 1-866-234-2345. Precautions Before taking alectinib, tell your doctor or pharmacist if you are allergic to it or if you have any other … WebAction. Description: Alectinib is a potent and highly selective inhibitor of anaplastic lymphoma kinase (ALK) and rearranged during transfection (RET) tyrosine kinase. It inhibits ALK phosphorylation and ALK-mediated activation of the downstream signalling proteins (STAT3 and AKT), leading to decreased viability of tumour cells in multiple cell ... WebAlectinib can cause serious or life-threatening side effects. Call your doctor right away if you have: heart problems --severe dizziness, very slow heartbeats; lung problems --fever, chest pain, cough, trouble breathing; kidney problems --a change in your urine color, little or no urination, swelling in your lower legs; or liver problems --upper stomach pain, dark urine, … cumberland county pennsylvania genealogy