CTLA-4 or CTLA4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in … See more CTLA-4 was first identified in 1991 as a second receptor for the T cell costimulation ligand B7. In November 1995, the labs of Tak Wah Mak and Arlene H. Sharpe independently published their findings on the … See more CTLA-4 is a member of the immunoglobulin superfamily that is expressed by activated T cells and transmits an … See more Variants in this gene have been associated with Type 1 diabetes, Graves' disease, Hashimoto's thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated … See more • Liossis SN, Sfikakis PP, Tsokos GC (August 1998). "Immune cell signaling aberrations in human lupus". Immunologic Research. 18 (1): 27–39. doi:10.1007/BF02786511 See more The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms, have been characterized. The … See more CTLA-4 has been shown to interact with: • AP2M1, • CD80, • CD86, See more • Human CTLA4 genome location and CTLA4 gene details page in the UCSC Genome Browser. • Overview of all the structural … See more WebNov 10, 2024 · CTLA-4 binds strongly to dimeric CD80 independent of intracellular pH, whereas it binds weakly to monomeric CD86 in a pH-sensitive manner. This results in differential subcellular trafficking ...
What does CTLA-4 mean? - Medical - Definition Meaning
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WebWhat does CTLA stand for in Accounting? Get the top CTLA abbreviation related to Accounting. Suggest. CTLA Accounting Abbreviation. What is CTLA meaning in … WebCTLA is an abbreviation for Cytotoxic T Lymphocyte Antigen. Share this. Have you found the page useful? Please use the following to spread the word: APA ... WebTwo proteins on the surface of T cells--CD28 and cytotoxic T-lymphocyte antigen 4 (CTLA-4)--play important roles in the regulation of immune activation and tolerance. CD28 provides positive modulatory signals in the early stages of an immune response, while CTLA-4 signaling inhibits T-cell activation, particularly during strong T-cell responses. csbg cares act funds